What is the link between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)?

Updated: Jun 14, 2018
  • Author: Howard S Kirshner, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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As mentioned above, patients with amyotrophic lateral sclerosis (ALS) develop behavioral and cognitive changes, often consistent with behavioral-variant FTD. Most such cases have ubiquitin-immunoreactive inclusions found in the frontal cortex, and these have been associated with the C9ORF72 gene mutation. About 10% of patients with ALS have significant dysfunction in behavior and executive function, and some patients with FTD develop motor neuron disease as their illness progresses. [32, 35]

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