What is the role of the Lewy body composite risk score (LBCRS) in the diagnosis of dementia with Lewy bodies (DLB)?

Updated: Aug 08, 2019
  • Author: Howard A Crystal, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

A new test, called the Lewy body composite risk score (LBCRS), may help determine whether Lewy body pathology is contributing to dementia. The checklist was derived from clinical features in autopsy-verified cases of healthy controls, Alzheimer’s disease (AD), DLB, and PD with and without dementia. It was tested and validated in a cohort of 256 patients. The LBCRS was able to discriminate DLB from other causes of dementia. [20, 21]

The test consists of 10 yes-or-no questions: 4 covering motor symptoms (slow movements, rigidity or stiffness, balance problems with or without falls, and a resting tremor) and 6 covering nonmotor symptoms (excessive daytime sleepiness, episodes of illogical thinking, frequent staring spells, visual hallucinations, acting out dreams, and orthostatic hypotension).


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