What other agents have demonstrated prolonged total sleep time at night in patients with Alzheimer disease (AD)?

Updated: May 09, 2019
  • Author: Shaheen E Lakhan, MD, PhD, MS, MEd; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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A 2016 meta-analysis of seven studies demonstrated prolonged total sleep time at night with melatonin, however, without improvement in cognitive abilities assessed by the mini-mental state examination and the Alzheimer's Disease Assessment Cognitive Subscale. [127]

Research on the effects of prescribing hypnotics such as zolpidem, zopiclon, or zaleplon to treat sleep problems in dementia patients found that these so-called Z drugs significantly increase fracture risk. In the study, at two-year follow-up, overall fracture risk increased by 40% and the risk for hip fracture by 59%. [128]

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