Is memantine (Namenda, Namenda XR) effective for the treatment of Alzheimer disease (AD)?

Updated: May 09, 2019
  • Author: Shaheen E Lakhan, MD, PhD, MS, MEd; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

Several studies have demonstrated that memantine can be safely used in combination with ChEIs. The combination of memantine with a ChEI has been shown to significantly delay institutionalization in AD patients. [105] Studies suggest that the use of memantine with donepezil affects cognition in moderate to severe AD [106] but not in mild to moderate AD. [107, 108]  A once-daily, fixed-dose combination of memantine extended-release (ER) and donepezil (Namzaric) was approved by the FDA in 2014. [109] Dizziness, headache, and confusion are some of the most common side effects of memantine.


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