What is the role of the receptor for advanced glycation end products (RAGE) in the pathogenesis of Alzheimer disease (AD)?

Updated: May 09, 2019
  • Author: Shaheen E Lakhan, MD, PhD, MS, MEd; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Answer

The apoptotic pattern of cellular death seen in oxidative stress is similar to that produced by Ab peptide exposure, and Ab neurotoxicity is attenuated by antioxidants such as vitamin E. Ab may induce toxicity by engaging several binding sites on the membrane surface. The receptor for advanced glycation end products (RAGE) may be one of these receptors. RAGE is a member of the immunoglobulin superfamily of cell surface molecules known for its capacity to bind advanced glycation end products.


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