What is included in medical care for the cutaneous manifestations of hepatitis C (Hep C)?

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Treatment of patients with extrahepatic dermatologic manifestations of hepatitis C virus (HCV) infection is the same as that of HCV infective state and the customary treatments of the individual conditions. Many, if not all, of the dermatologic manifestations disappear when appropriate HCV treatment or viral clearance occurs. HCV is the main cause of mixed cryoglobulinemia vasculitis, which should be treated, with new options including a combination of potent direct-actin antiviral agents and biological medications, especially rituximab. [89, 90] HCV-related cryoglobulinemic vasculitis and polyarteritis nodosa may merit antiviral therapy and corticosteroids. [91] Plasma exchange and/or combined cyclophosphamide and corticosteroid therapy can be considered in patients with severe life-threatening vasculitis manifestations. Malignant conditions may even disappear with effective therapy for the underlying chronic hepatitis C infection.

Currently, medical treatment of patients with HCV infection consists of interferon and ribavirin therapy. Medical therapy for patients with individual extrahepatic dermatologic manifestations of HCV infection depends on the condition.

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