Which physical findings are characteristic of dermatologic reactions to hepatitis C (Hep C) treatment?

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Lichen myxedematosus may worsen during interferon alfa-2a therapy for chronic active hepatitis. [86] Asymptomatic, 2- to 4-mm, flesh-colored papules on the upper and lower extensor surfaces of the arms are noted. Lichen myxedematosus papules contain depositions of mucin in patients without thyroid disease who often have paraproteinemias. A localized form affects the head and neck, upper limbs, lower limbs, or trunk. A generalized form is termed scleromyxedema and affects large areas with sclerosis.

Capillaritis is associated with interferon alfa treatment of HCV infection. [77] Pigmented purpuric eruptions on the lower legs consist of fine petechiae that appear after beginning treatment.

Erosive OLP and epidermolytic hyperkeratosis may occur during interferon alfa-2b therapy for chronic hepatitis C infection. These conditions appear with erythematous, scaly plaques on the scalp, chest, back, buttocks, legs, and genitalia and painful ulcerations in the mouth. The skin lesions are psoriasiform with a reddened base and variable heaped-up scale. Wickham striae occur on the lips and intraorally. [76]

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