Which dermatologic conditions may be present in patients with hepatitis C virus (HCV) infection?

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Erythema dyschromicum perstans is an asymptomatic condition of ashy gray discoloration of the skin on the extensor surfaces of the arms and face.

Porokeratosis, the disseminated superficial type, has been associated with HCV infection or hepatocellular carcinoma. Eruptive disseminated porokeratosis in relation to the onset of hepatocellular carcinoma occurred in 3 closely observed patients with chronic hepatitis C infection and persistent HCV hepatitis. Both conditions are believed to be related to immunomodulation of the TP53 gene. HCV core protein may affect cancer transformation directly through an effect on a promoter gene expression. [78] The core protein is a multifunctional protein with the capacity to bind to the so-called death domain of tumor necrosis factor receptor 1 (TNFR1) and the intracellular portion of lymphotoxin-beta receptor. The portion of TNFR1 active in apoptosis and antiapoptosis signaling pathway is the death domain affected by HCV. [29]

Generalized granuloma annulare, an asymptomatic condition with dermal nodule formation resulting from an inflammation of collagen, may be present. [79]

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