What is the clinical history of hepatoma in hepatitis C virus (HCV) infection?

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
  • Print

The progression of HCV infection to chronic hepatitis C infection and then to hepatocellular carcinoma is a well-known sequence. The chronicity of HCV infection occurs in 60% of patients infected by the virus overall, but the rate increases to more than 90% in type 1b infection. [14] Worse hepatocellular disease also resulted from type 1b infections. Hepatic cirrhosis is correlated with inoculation size, being more common in patients with HCV-infected blood transfusions (23%) and organ transplantation than in users of intravenous drugs (9%). Viral species variation, complications, and host antibody response vigor have a role in chronic infection. [75] Cirrhosis develops in approximately 15-20% of patients with chronic hepatitis C. Hepatocellular carcinoma eventually occurs in 5-10% of patients with chronic hepatitis C. Symptoms of hepatoma include rapid decompensation of the liver and metastases, often to the brain.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!