What is the prevalence of non-Hodgkin B-cell lymphoma (NHLB) in patients with hepatitis C virus (HCV) infection?

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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A study concerning the association of HCV and NHLB showed a prevalence of HCV of 37%. [27] Patients were older, and more patients were female than male. A closer association to immunocytoma than to MALT syndrome was found. In 20 patients with immunocytoma, 13 had HCV infection, and localization to the orbit and mucosal surfaces was more common. HCV localized to a parotid lymphoma associated with a mixed cryoglobulinemia showed viral proliferation in parotid epithelial cells and not in NHLB cells. [28]

Epstein-Barr virus and herpesvirus type 6 are the other sialotropic viruses not present in the reported cases. Local carcinogenic functions of HCV, effect on the p53 system, immunoregulation perturbations, and malignant transformation were considered in the etiology of the conditions.

HCV patients with B-cell lymphoma and Sjögren syndrome have a high frequency of parotid enlargement and vasculitis, an immunologic pattern overwhelmingly dominated by the presence of rheumatoid factor and mixed type II cryoglobulins, a predominance of MALT lymphomas, and an elevated frequency of primary extranodal involvement in organs in which HCV replicates (eg, exocrine glands, liver, stomach). [74]

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