What are the signs and symptoms of non-Hodgkin B-cell lymphoma in chronic hepatitis C (CHC) disease?

Updated: Apr 02, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

A high prevalence (20-40%) of HCV antibodies occurs in non-Hodgkin B-cell lymphoma (NHLB), and the antibodies are not present in other lymphomas or hematologic malignancies. [68] Lymphomas producing cryoglobulins and low-grade mucosa-associated lymphoma tumors (ie, MALT syndrome) of the GI tract are associated with dermatologic manifestations. Antigen-driven B-cell proliferation from chronic stimulation is the proposed mechanism. [69, 70, 14, 71, 72] NHLB presents like other lymphomas, with lymphoidal masses, gut associated masses, and symptoms of cryoglobulinemia with palpable purpura and ulcers of the lower legs.


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