What are the signs and symptoms of erythema multiforme in hepatitis C (Hep C)?

Updated: Apr 02, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

Bull's-eye lesions characterize the skin reaction pattern of erythema multiforme (EM). EM can be asymptomatic, pruritic, or burning. As an immune response to adverse antigenic stimuli from endogenous or exogenous sources, the response can be limited to a few, many, or widespread urticarial lesions with surrounding erythema and central deeply erythematous spots. Overwhelming reactions of this type include oral and anal ulcerations, systemic symptoms, and prostration; this condition is termed Stevens-Johnson syndrome. HCV infection is just one of many possible causes of EM.

Note the images below:

Erythema multiforme. Courtesy of Walter Reed Army Erythema multiforme. Courtesy of Walter Reed Army Medical Center Dermatology.
Erythema multiforme. Courtesy of Walter Reed Army Erythema multiforme. Courtesy of Walter Reed Army Medical Center Dermatology.
Erythema multiforme. Courtesy of Walter Reed Army Erythema multiforme. Courtesy of Walter Reed Army Medical Center Dermatology.
Erythema multiforme of the oral mucosa. Courtesy o Erythema multiforme of the oral mucosa. Courtesy of Walter Reed Army Medical Center Dermatology.
Erythema multiforme (Stevens-Johnson syndrome). Co Erythema multiforme (Stevens-Johnson syndrome). Courtesy of Walter Reed Army Medical Center Dermatology.

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