What are the signs and symptoms of erythema nodosum in hepatitis C (Hep C)?

Updated: Apr 02, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

A nonspecific association, erythema nodosum (EN) has multiple causes considered in the differential diagnosis, including viral infections. EN appears as erythematous, tender, dome-shaped elevations on the skin on the lower legs. EN lesions can be single or multiple, and they can demonstrate a reaction pattern on the skin resulting from panniculitic inflammation generated by various pathologic sources (eg, infections with bacteria, mycobacteria, Protozoa, fungi, viruses).

Note the images below:

Erythema nodosa. Courtesy of Walter Reed Army Medi Erythema nodosa. Courtesy of Walter Reed Army Medical Center Dermatology.
Erythema nodosa. Courtesy of Walter Reed Army Medi Erythema nodosa. Courtesy of Walter Reed Army Medical Center Dermatology.

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