What are possible secondary disorders of chronic hepatitis C (CHC)?

Updated: Apr 19, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

Note the following:

  • Behçet disease: Behçet syndrome is believed to result from an unknown immunologic cause and results in a vasculitis that can cause coagulation and destruction of arteries and veins.

  • Canities: Illness and disease can affect melanogenesis of the hair.

  • Prurigo nodularis: A report of HCV infection with prurigo nodularis has been published. [21]

  • Lichen planus: Lichen planus is most likely an immunologically mediated reaction.

  • Sialadenitis: This condition may result from an HCV infection in the salivary gland epithelium and may be a primary disorder of the glands.

  • Thyroiditis: Destructive inflammation results in early hyperthyroidism. As more of the gland is destroyed, thyroid function normalizes and then becomes subnormal in a hypothyroid picture.

  • Thrombocytopenia: Thrombocytopenia may be due to a number of causes. These include disorders producing diminished platelet production, altered platelet distribution, and increased platelet destruction. For example, an acute viral infection may produce an acquired defect in diminished platelet production. Medications may give increased platelet destruction. Low platelet counts result in the spontaneous asymptomatic appearance of flat areas of petechiae, purpura, and ecchymosis of the skin.

  • Vitiligo: A case of hair turning white as a result of HCV infection was reported.


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