What are the types of cryoglobulinemia caused by hepatitis C (Hep C)?

Updated: Apr 02, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
  • Print
Answer

Type I cryoglobulinemias are caused by macroglobulins, such as in Waldenström macroglobulinemia, or IgG in which sludging results from massive molecules congealing in cooled venules of the lower leg.

Type II mixed cryoglobulins have a monoclonal rheumatoid species but vary in the IgG antigen, which is nonspecific.

Type III mixed cryoglobulinemias result from specific reactions of immunoglobulins to a single or well-defined antigen or various antigens, but the antibody species and the antigen are not monoclonal.

HCV-related systemic vasculitis may also occur in the absence of detectable mixed cryoglobulinemia. [21]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!