What is the pathogenesis of type II cryoglobulinemia in hepatitis C virus (HCV)?

Updated: Apr 02, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

Type II cryoglobulinemias in which IgM is the macromolecular rheumatoid antibody are more common than type III cryoglobulinemias. IgG was directed toward NS proteins and structural proteins. IgM antigen was the core protein, suggesting cross-reactivity to IgG. [20] Co-affinity of IgM anticore antibody to IgG may be a mechanism in the formation of the cryoprecipitate.


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