What are the genotypes of hepatitis C virus (HCV)?

Updated: Apr 19, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

The last category is suspected associations of the disorder in a causative schema. HCV genomic analysis by means of arduous gene sequencing of many viruses has led to the division of HCV into genotypes based on homology. Arabic numerals denote the genotype, and a letter denotes the subtype for lesser homology within each genotype. [11] Note the following:

  • Genotype 1a occurs in 50-60% of patients in the United States. This type is difficult to eradicate using current medications.

  • Genotype 1b occurs in 15-20% of patients in the United States. Subtype 1b is difficult to eradicate using current medications. This type is most prevalent in Europe, Turkey, and Japan.

  • Genotype 1c occurs in less than 1% of patients in the United States.

  • Genotypes 2a, 2b, and 2c occur in 10-15% of patients in the United States. These subtypes are widely distributed and are most responsive to medication.

  • Genotypes 3a and 3b occur in 4-6% of patients in the United States. These subtypes are most prevalent in India, Pakistan, Australia, and Scotland.

  • Genotype 4 occurs in less than 5% of patients in the United States. It is most prevalent in the Middle East and Africa.

  • Genotype 5 occurs in less than 5% of patients in the United States. It is most prevalent in South Africa.

  • Genotype 6 occurs in less than 5% of patients in the United States. It is most prevalent in Hong Kong and Macao.


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