How are noninfectious and nonmalignant cutaneous manifestations of HIV disease treated?

Updated: Apr 19, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Answer

Answer

For xerosis, emollients and dry skin care regimens are effective. For seborrheic dermatitis, coal tar, sulfur, and salicylic acid shampoos; topical corticosteroids; topical tacrolimus; and 2% ketoconazole cream may be effective.

For psoriasis and Reiter syndrome, ultraviolet B (UV-B) and psoralen with UV-A (PUVA) may be useful. Systemic corticosteroids, methotrexate, and cyclosporine may increase the immune suppression and must be considered only with careful monitoring. Zidovudine is also reported to be useful in the treatment of HIV-associated psoriasis.

For pruritic papular eruption, topical steroids, UV-B, PUVA, and pentoxifylline [61] have been reported to be effective. Eosinophilic folliculitis may respond to UV-B, [62] isotretinoin, or zidovudine treatment. For severe aphthous stomatitis, tacrolimus is reported to be effective.


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