Which dermatologic conditions are associated with HIV disease?

Updated: Apr 19, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Answer

Answer

The following dermatologic conditions may be associated with HIV disease:

  • HIV-related CD8+ cutaneous pseudolymphoma: This is an inflammatory process that results from a massive infiltration of the skin by activated, oligoclonal, HIV-specific, cytotoxic T lymphocytes and is most often seen in those that are markedly immunosuppressed. [48]

  • Cutaneous vasculitis (possibly caused by CMV or parvovirus B19) [49]

  • Leukocytoclastic vasculitis with indinavir treatment [50]

Thrombocytopenic purpura, vitiligo, alopecia areata, sicca syndrome, pemphigoid, and other autoimmune blistering diseases have been reported in association with HIV disease.

Atopic disease may be reactivated by HIV disease. Atopic eczema may be severe in children infected with HIV. Increased serum IgE levels have been found in these children; however, increased IgE levels were not correlated with atopic symptoms. [51]

Urticaria may occur primarily or as a drug eruption in HIV disease. Cold urticaria has also been associated with HIV disease. [52]


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