What are the cutaneous manifestations of deep fungal infections in HIV disease?

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Rarely, cutaneous cryptococcosis may be observed in patients with HIV infection. [32] Clinical manifestations include the following:

  • Cellulitis

  • Papules

  • Plaques

  • Ulcers

  • Translucent dome-shaped papules with central umbilication, resembling MC

Cutaneous histoplasmosis may lead to red papules, a cellulitislike eruption, ulcerations, acneiform papules, or molluscumlike lesions in patients infected with HIV. [33, 34]

North American blastomycosis may present as a disseminated maculopapular eruption in HIV disease.

Systemic coccidioidomycosis may disseminate to the skin, usually as hemorrhagic papules or nodules. A positive culture/staining from pus and cutaneous lesions may be used to document the cryptococcosis. [35]

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