Which medications in the drug class Retinoid-like Agents are used in the treatment of Nongenital Warts?

Updated: Sep 25, 2020
  • Author: Philip D Shenefelt, MD, MS; Chief Editor: William D James, MD  more...
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Retinoid-like Agents

Retinoidlike agents may be helpful in immunocompromised patients with extensive disabling hyperkeratotic warts. They may help alleviate pain and facilitate the use of other treatments. In addition, retinoids have helped reduce the number of lesions in immunosuppressed renal transplant patients. Topical retinoids may be useful in treating flat warts.

Isotretinoin (Amnesteem, Claravis, Myorisan, Sotrel)

Isotretinoin is a synthetic 13-cis isomer of the naturally occurring tretinoin (trans -retinoic acid); it is structurally related to vitamin A. It is approved for severe nodular acne but has also been helpful in certain keratinization disorders.

A US Food and Drug Administration–mandated registry is now in place for all individuals prescribing, dispensing, or taking isotretinoin. For more information on this registry, see iPLEDGE. This registry aims to further decrease the risk of pregnancy and other unwanted and potentially dangerous adverse effects during a course of isotretinoin therapy. It may be administered at 0.5-2 mg/kg/d PO divided bid with food.

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