What causes nongenital warts?

Updated: Sep 25, 2020
  • Author: Philip D Shenefelt, MD, MS; Chief Editor: William D James, MD  more...
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Answer

Warts are caused by HPV, which is a double-stranded, circular, supercoiled DNA virus enclosed in an icosahedral capsid and comprising 72 capsomers. More than 100 types of HPV have been identified. Note the following wart types and HPV types:

  • Common warts - HPV types 2 and 4 (most common), followed by types 1, 3, 27, 29, and 57

  • Deep palmoplantar warts (myrmecia) - HPV type 1 (most common), followed by types 2, 3, 4, 27, 29, and 57

  • Flat warts - HPV types 3, 10, and 28

  • Butcher's warts - HPV type 7 (although some data suggest the association may be weak)

  • Focal epithelial hyperplasia (Heck disease) - HPV types 13 and 32

  • Cystic warts - HPV type 60


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