What are the demographics of roseola infantum?

Updated: Oct 09, 2020
  • Author: Christopher R Gorman, MD; Chief Editor: William D James, MD  more...
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Answer

With rare geographic exceptions, no racial differences seem to occur in HHV-6 infection.

Sex

Zerr et al reported HHV-6 acquisition is associated with female sex and having older siblings. [6]

Age

Antibody titers are high in newborns because of maternal antibody. Transplacental infection occurs in about 1% of cases. Titers decrease from 3-9 months of age and then begin to rise because of primary infections. Titers remain high for HHV-6B until after age 60 years. Infection with HHV-6A appears later in life. In roseola infantum, age ranges from 2 weeks to 3 years. In one study, almost one fourth of the patients were younger than 6 months. In a Brazilian study, 75% of HHV-6 infections occurred in children aged 6-17 months. [7]


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