Which medications in the drug class Analgesics, Topical are used in the treatment of Herpes Zoster?

Updated: Jan 25, 2019
  • Author: Camila K Janniger, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Analgesics, Topical

Topical analgesics containing capsaicin have been shown to be effective for temporary relief of neuropathic pain.

Capsaicin (Capzasin-P, Zostrix)

Capsaicin is derived from plants of the Solanaceae family. It is a transient receptor potential vanilloid-1 (TRPV1) agonist indicated for neuropathic pain associated with PHN. TRPV1 is an ion channel–receptor complex expressed on nociceptive skin nerve fibers. Topical capsaicin causes initial TRPV1 stimulation that may cause pain, followed by pain relief via a reduction in TRPV1-expressing nociceptive nerve endings. Neuropathic pain may gradually recur over several months, an event thought to be caused by TRPV1 nerve fiber reinnervation of the treated area.

Capsaicin transdermal patch (Qutenza)

Capsaicin is a TRPV1 agonist indicated for neuropathic pain associated with postherpetic neuralgia. Topical capsaicin causes initial TRPV1 stimulation that may cause pain, followed by pain relief via a reduction in TRPV1-expressing nociceptive nerve endings. Neuropathic pain may gradually recur over several months; this recurrence is thought to be caused by TRPV1 nerve fiber reinnervation of the treated area.


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