Which medications in the drug class Antidepressants, TCAs are used in the treatment of Herpes Zoster?

Updated: Feb 11, 2021
  • Author: Camila K Janniger, MD; Chief Editor: Dirk M Elston, MD  more...
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Antidepressants, TCAs

TCAs have been shown to play a role in the treatment of PHN.


Amitriptyline blocks the reuptake of norepinephrine and serotonin. It decreases pain by inhibiting spinal neurons involved in pain perception.

Desipramine (Norpramin)

Desipramine is a tricyclic antidepressant that, of the first-generation TCAs, has the least adverse effects. These agents have been found to be effective in relieving PHN.

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