How are central nervous system (CNS) complications of herpes zoster (shingles) differentiated from other forms of meningoencephalitis?

Updated: Feb 11, 2021
  • Author: Camila K Janniger, MD; Chief Editor: Dirk M Elston, MD  more...
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In severely ill or immunocompromised patients, general central nervous system (CNS) involvement can be observed in the form of meningoencephalitis or encephalitis. Such presentations are indistinguishable from other forms of meningoencephalitis, though other evidence of acute herpes zoster usually is present. [12] Cerebrospinal fluid (CSF) studies frequently reveal pleocytosis without elevated protein. These infections can be-life threatening.

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