What are the associations between inflammatory bowel disease (IBD) and herpes zoster (shingles)?

Updated: Mar 17, 2020
  • Author: Camila K Janniger, MD; Chief Editor: Dirk M Elston, MD  more...
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Research indicates that patients with inflammatory bowel disease (IBD) are at significantly increased risk for herpes zoster. [11] In an analysis of more than 108,000 IBD patients and 430,000 matched controls, the overall annual incidence per 100,000 person-years was 734 among IBD patients, compared with 437 in non-IBD patients. The elevated risk in IBD patients remained after adjustment for comorbidities and other factors. Treatment with thiopurines, corticosteroids, and biologic antitumor necrosis factor–alpha (anti-TNF) agents was independently associated with an increased risk of herpes zoster. [39, 40]

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