What is the efficacy of systemic antiviral therapy for genital herpes?

Updated: Feb 16, 2018
  • Author: Sean P McGregor, DO, PharmD; Chief Editor: William D James, MD  more...
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Answer

Treatment with systemic antivirals leads to faster healing and resolution of symptoms by 1-2 days. Viral shedding is also reduced as a result of treatment. All of the systemic antivirals have similar efficacy. A study that compared famciclovir 1000 mg twice daily for a single day and valacyclovir 500 mg twice daily for 3 days found no difference in the reduction in healing time. [43] Similar results with regard to long-term suppressive therapy have been observed among the systemic antivirals.


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