What is the dermatologic preoperative evaluation and management of colchicine, penicillamine, isotretinoin, and phenytoin?

Updated: Mar 16, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Several other systemic medications have been cited as wound inhibitors, primarily in animal studies. These medications include colchicine, penicillamine, isotretinoin, and phenytoin. Penicillamine decreases wound tensile strength at clinical dosages. Colchicine may have antifibroblastic properties. These agents are best considered to be minimal inhibitors of wound healing in surgery. Patients who are considering ablative skin resurfacing should have isotretinoin discontinued for 6 months before treatment.

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