What is the dermatologic preoperative evaluation and management of antineoplastic and immunosuppressive agents?

Updated: Mar 16, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

Answer

Many antineoplastic and immunosuppressive agents have been thought to retard wound healing. Alkylating agents, antimetabolites, and antibiotics have all been considered inhibitors of wound healing. Actinomycin, bleomycin, or carmustine (BCNU) causes greater impairment than does vincristine, methotrexate, 5-fluorouracil, or cyclophosphamide. Most of these drugs have little effect on minor dermatologic surgical procedures. However, the use of immunosuppressive or antineoplastic agents may predispose the patient to an even greater risk of infection, and physicians may consider the use of prophylactic antibiotics.


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