Which medications in the drug class Antihistamines, 1st Generation are used in the treatment of Wells Syndrome?

Updated: Apr 17, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
  • Print

Antihistamines, 1st Generation

H1 receptor antagonists act by competitive inhibition of histamine at the H1 receptor. This mediates the wheal-and-flare reactions, bronchial constriction, mucous secretion, smooth muscle contraction, edema, hypotension, CNS depression, and cardiac arrhythmias. These first-generation antihistamines should be used with caution, as they have poor receptor selectivity, cross the blood-brain barrier, reduce rapid eye movement (REM) sleep, and interfere with histaminergic transmission. Histamine is a vital neurotransmitter that increases arousal in the circadian sleep-wake cycle and reinforces learning and memory.


Cyproheptadine is used for the symptomatic relief of allergic symptoms caused by histamine released in response to allergens and skin manifestations.

Diphenhydramine (AllerMax, Aller-Cap, Anti-Hist, Benadryl)

Diphenhydramine is used for the symptomatic relief of symptoms caused by release of histamine in allergic reactions.

Chlorpheniramine (Chlor-Trimeton, Teldrin, Aller-Chlor, Chlor-Hist)

Chlorpheniramine is used to treat intense, localized allergic reactions. This agent competes with histamine or H1-receptor sites on effector cells in blood vessels and the respiratory tract.

Hydroxyzine hydrochloride (Vistaril)

Hydroxyzine hydrochloride antagonizes H1 receptors in the periphery. It may suppress histamine activity in the subcortical region of the central nervous system (CNS).

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!