What is the role of medications in the treatment of Wells syndrome (eosinophilic cellulitis)?

Updated: Apr 17, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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The medications used for the treatment of eosinophilic cellulitis include antifungals, such as griseofulvin; antibiotics, such as dapsone; immunosuppressants, such as cyclosporine and cortisone; and H1 receptor antagonists, such as cyproheptadine and diphenhydramine. [51] First-generation antihistamines should be used with caution, as they have poor receptor selectivity, cross the blood-brain barrier, reduce rapid eye movement (REM) sleep, and interfere with histaminergic transmission. [52] Since it tends to resolve, systemic treatment should be used cautiously. [52]

Systemic corticosteroids are the most effective treatment, but they may lead to corticosteroid dependence.

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