What are the signs and symptoms of Wells syndrome (eosinophilic cellulitis)?

Updated: Apr 17, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Usually, the patient with Wells syndrome (eosinophilic cellulitis) reports pruritus or a burning sensation, which is followed by erythema and edema. Occasionally, papular and nodular eruptions may be seen first. Typically, a tender or mildly pruritic cellulitis-like eruption occurs. The clinical presentation may also include annular plaques, vesicles and bullae (bullous Wells syndrome associated with non-Hodgkin lymphoma [37] ), and urticaria. [38]

Systemic symptoms, including asthma, arthralgia, and fever, may be evident, although they usually do not occur. Although long-term sequelae usually do not result, reticular pigmentation and scarring alopecia may occur. Rarely, Wells syndrome is associated with life-threatening diseases such leukemia and lymphoma. [23, 39, 40] However, at this point, determining if these are coincidental findings or real associations is impossible.

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