Which medications in the drug class Chelators are used in the treatment of Vesicular Palmoplantar Eczema?

Updated: Aug 23, 2019
  • Author: Jessica Dunkley, MD, MHSc, CCFP; Chief Editor: Dirk M Elston, MD  more...
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Answer

Chelators

These drugs split into two molecules of sodium diethyldithiocarbamate after absorption, which, in turn, chelates divalent metal ions (eg, Ni++) and results in the increased urinary excretion of nickel. They are effective in the treatment of vesicular palmoplantar dermatitis in nickel-hypersensitive patients whose eczema is aggravated by an oral challenge with nickel.

Disulfiram (Antabuse)

Disulfiram is a thiuram derivative that interferes with aldehyde dehydrogenase. The chelating effect is helpful in reducing the nickel burden in patients allergic to nickel.


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