Which medications in the drug class Dermatologics, Other are used in the treatment of Vesicular Palmoplantar Eczema?

Updated: Aug 23, 2019
  • Author: Jessica Dunkley, MD, MHSc, CCFP; Chief Editor: Dirk M Elston, MD  more...
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Dermatologics, Other

PUVA therapy is used to treat many skin conditions, including psoriasis, eczema, urticaria, mycosis fungoides, vitiligo, and palmoplantar pustular dermatoses.

The drug 8-methoxypsoralen (8-MOP) is taken 2 hours before exposure to UVA irradiation. The initial UVA irradiation dose of 0.5 J/cm2 is usually increased by 0.5 J/cm2 for approximately six treatments, then by 1 J/cm2 per treatment for a total of 25-35 treatments.

Local bath-PUVA therapy has been successful in treating palmoplantar eczema and psoriasis. Compared with systemic PUVA, local-bath therapy has several advantages, particularly the absence of phototoxicity, severe hyperpigmentation, and protracted photosensitivity. The drug 8-MOP in a 0.15% alcoholic solution is added to tap water (37°C) at a concentration of 1 mg 8-MOP/L (0.0001%). After a 15-minute bath, the palms or soles are exposed to UVA radiation.

Methoxsalen (Oxsoralen-Ultra, Uvadex, 8-MOP)

Methoxsalen inhibits mitosis by covalently binding to pyrimidine bases in DNA when photoactivated by UVA.

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