What is the role of crisaborole in the treatment of vesicular palmoplantar eczema?

Updated: Aug 23, 2019
  • Author: Jessica Dunkley, MD, MHSc, CCFP; Chief Editor: Dirk M Elston, MD  more...
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Answer

Crisaborole is a novel boron-based small molecule that inhibits phosphodiesterase 4 and decreases intracellular cyclic adenosine monophosphate. It leads to lowered release of cytokines and decreased inflammation. It has been demonstrated to have efficacy in the treatment of mild-to-moderate atopic dermatitis. [62] Its efficacy in vesicular palmoplantar eczema has not been established.


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