What is transient acantholytic dermatosis (Grover disease)?

Updated: Mar 17, 2020
  • Author: Clay J Cockerell, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Transient acantholytic dermatosis (Grover disease) is not an uncommon condition, but, surprisingly, it was not thoroughly characterized until Grover did so in 1970. [1] Transient acantholytic dermatosis is characterized by papulovesicular eruptions on the trunk and proximal extremities. Transient acantholytic dermatosis is a reactive skin condition that resolves over a period of weeks or months, but it is more likely to be persistent (chronic). While generally accepted to be a benign, self-limited disorder, it is often persistent and difficult to manage; hence, the description of transient is misleading. [2] The presentation can be subtle, or it may closely resemble other pruritic dermatoses. A high index of suspicion for this disease is necessary if the diagnosis is to be made correctly. Furthermore, the histologic features of transient acantholytic dermatosis (Grover disease) closely resemble those of several other conditions that are clinically distinct, which may add to potential diagnostic confusion.


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