What is the role of the Kveim-siltzbach test in the diagnosis of sarcoidosis?

Updated: Oct 01, 2020
  • Author: Joseph F Merola, MD, MMSc; Chief Editor: Dirk M Elston, MD  more...
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The Kveim test is the most specific test for sarcoidosis. It is not commonly available, nor commonly used, because of difficulty in obtaining a validated antigen source, as well as a fear of transmitting infection. The Kveim test involves intradermal injection of tissue from the spleen or the lymph node of a patient with sarcoidosis. A biopsy sample is obtained from the area 4-6 weeks after injection and is histologically examined for noncaseating granuloma formation, which, if found, indicates a positive result.

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