Which medications in the drug class Blood Components are used in the treatment of Pyoderma Gangrenosum?

Updated: Mar 09, 2020
  • Author: J Mark Jackson, MD; Chief Editor: William D James, MD  more...
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Answer

Blood Components

These agents are used to improve the clinical and immunologic aspects of the disease. They may decrease autoantibody production and increase solubilization and removal of immune complexes.

IV immunoglobulins (Octagam, Hizentra, Gammagard, Gamunex)

IV immunoglobulin neutralizes circulating myelin antibodies through anti-idiotypic antibodies; down-regulates proinflammatory cytokines, including interferon (INF)-gamma; blocks Fc receptors on macrophages; suppresses inducer T and B cells and augments suppressor T cells; blocks complement cascade; and promotes remyelination. It may increase cerebrospinal fluid (CSF) IgG (10%).


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