Which medications in the drug class Antibiotics are used in the treatment of Nummular Dermatitis (Nummular Eczema)?

Updated: Aug 16, 2019
  • Author: Jami L Miller, MD; Chief Editor: William D James, MD  more...
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Answer

Antibiotics

Antibiotics are used for severe exudative flares with infection. Empiric antimicrobial therapy should cover S aureus and other likely pathogens in the context of the clinical setting.

Sulfamethoxazole and trimethoprim (Bactrim)

Sulfamethoxazole and trimethoprim combination agent inhibits bacterial growth by inhibiting the synthesis of dihydrofolic acid. The antibacterial activity of TMP-SMZ includes common urinary tract pathogens, except Pseudomonas aeruginosa. It is also used for MRSA infections.

Dicloxacillin (Dynapen, Pathocil, Dycill)

Dicloxacillin binds to one or more penicillin-binding proteins, which, in turn, inhibits the synthesis of bacterial cell walls. Dicloxacillin is used for the treatment of infections caused by penicillinase-producing staphylococci. It may be used to initiate therapy when staphylococcal infection is suspected.

Erythromycin (E.E.S., E-Mycin, Eryc)

Erythromycin inhibits bacterial growth, possibly by blocking dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest. It is used for the treatment of staphylococcal and streptococcal infections.

In children, age, weight, and severity of infection determine proper dosage. When twice-daily dosing is desired, half the total daily dose may be taken every 12 hours. For more severe infections, double the dose.

Cephalexin (Biocef, Keflex, Keftab)

Cephalexin is a first-generation cephalosporin that arrests bacterial growth by inhibiting the synthesis of bacterial cell walls. It has bactericidal activity against rapidly growing organisms. Its primary activity is against skin flora. Cephalexin is used for skin infections or prophylaxis in minor procedures.


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