What other uncommon factors may play a role in the etiology of nummular dermatitis?

Updated: Aug 16, 2019
  • Author: Jami L Miller, MD; Chief Editor: William D James, MD  more...
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Answer

Onset of severe, generalized nummular lesions has been reported in association with interferon therapy for hepatitis C as well as exposure to mercury. [17]

Various types of eczematous eruptions, including nummular eczema, have been observed following tumor necrosis factor-alpha–blocking therapy. [8]

Nummular eczema of the breast has reported in breast cancer patients undergoing mastectomy with subsequent breast reconstruction. [18, 19]

Nummular eczema has been found in association with infection in rare cases. Giardiasis has been reported. [20] One study reported that in patients with Helicobacter pylori infection and nummular dermatitis, eradication of H pylori caused clearance of the skin lesions in 54% of the patients. [21] Another case report noted nummular eczema in association with a dental infection that cleared after the treatment of the infection. [22]


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