What is the role of mast cell dysfunction in the pathophysiology of nummular dermatitis?

Updated: Nov 21, 2019
  • Author: Jami L Miller, MD; Chief Editor: William D James, MD  more...
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Answer

Other research has demonstrated that mast cells present in the dermis of patients with nummular eczema may have decreased chymase activity, imparting reduced ability to degrade neuropeptides and protein. This dysregulation could lead to decreased capability of the enzyme to suppress inflammation.


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