Which medications in the drug class Corticosteroids are used in the treatment of Lichen Simplex Chronicus?

Updated: Feb 15, 2019
  • Author: Jason Schoenfeld, MD; Chief Editor: William D James, MD  more...
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Answer

Corticosteroids

Corticosteroids have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli.They decrease pruritus, thin lichenification, and reduce inflammation.

Clobetasol (Temovate)

Clobetasol is a class I superpotent topical steroid; it suppresses mitosis and increases the synthesis of proteins that decrease inflammation and cause vasoconstriction.

Betamethasone dipropionate cream 0.05% (Diprolene, Betatrex)

Betamethasone dipropionate cream 0.05% is for inflammatory dermatoses responsive to steroids. It decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. It affects the production of lymphokines and has an inhibitory effect on Langerhans cells.

Fluocinolone 0.01% or 0.025% cream (Synalar, Synalar HP, Fluonid)

Fluocinolone is a medium potency topical corticosteroid that inhibits cell proliferation; it also is immunosuppressive, antiproliferative, and anti-inflammatory. Flurandrenolide tape (4 mcg/cm2; Cordran tape) combines a topical steroid with the benefits of occlusion and is classified as a group I (potency) preparation.

Triamcinolone topical (Perrigo)

Triamcinolone topical is for inflammatory dermatoses responsive to steroids; it decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability.

Hydrocortisone valerate cream 0.2% (Westcort)

Hydrocortisone valerate cream is an adrenocorticosteroid derivative suitable for application to skin or external mucous membranes. It has mineralocorticoid and glucocorticoid effects, resulting in anti-inflammatory activity.

Fluocinonide

Fluocinonide is a high-potency topical corticosteroid that inhibits cell proliferation. It has immunosuppressive and anti-inflammatory properties.


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