Which medications in the drug class Immunosuppressant Agent are used in the treatment of Lichen Simplex Chronicus?

Updated: Feb 15, 2019
  • Author: Jason Schoenfeld, MD; Chief Editor: William D James, MD  more...
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Answer

Immunosuppressant Agent

Tacrolimus ointment (Protopic)

Tacrolimus ointment's mechanism of action in LSC is unknown. It reduces itching and inflammation by suppressing the release of cytokines from T cells. It also inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha, all of which are involved in the early stages of T-cell activation. Additionally, it may inhibit the release of preformed mediators from skin mast cells and basophils and down-regulate the expression of FCeRI on Langerhans cells. It can be used in patients as young as 2 years. Drugs of this class are more expensive than topical corticosteroids. It is available as ointment in concentrations of 0.03 and 0.1%. It is indicated only after other treatment options have failed.


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