What histologic findings are associated with lichen simplex chronicus?

Updated: Feb 15, 2019
  • Author: Jason Schoenfeld, MD; Chief Editor: William D James, MD  more...
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Answer

Histologic examination demonstrates hyperkeratosis, acanthosis, spongiosis, and patches of parakeratosis in the epidermis. Epidermal thickening of all layers is noted, with elongation of rete ridges and with pseudoepitheliomatous hyperplasia. Papillary dermal fibrosis with vertical streaking of collagen bundles is characteristic.

A characteristic finding of lichen simplex chronicus that is noted on electron microscopy is frequent collagen fibers attached to and just above the lamina basalis.

H and E biopsy of lichen simplex chronicus from fo H and E biopsy of lichen simplex chronicus from forearm skin viewed at 40x magnification. Note the characteristic hyperkeratosis, hypergranulosis, pseudoepitheliomatous hyperplasia, and papillary dermal fibrosis.
H and E biopsy of lichen simplex chronicus from fo H and E biopsy of lichen simplex chronicus from forearm skin viewed at 100x magnification. Note the characteristic hyperkeratosis, hypergranulosis, pseudoepitheliomatous hyperplasia, and papillary dermal fibrosis.

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