What is the role of P-phenylenediamine (PPD) in the pathophysiology of lichen simplex chronicus (LCS)?

Updated: Feb 15, 2019
  • Author: Jason Schoenfeld, MD; Chief Editor: William D James, MD  more...
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Answer

A small study looking at lichen simplex chronicus and the use of P-phenylenediamine (PPD)–containing hair dye showed clinically relevant improvement in symptoms after discontinuation of PPD exposure, [7] thus providing a basis for the role of sensitization and contact dermatitis in the etiology of lichen simplex chronicus.


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