Which medications in the drug class Corticosteroids are used in the treatment of Lichen Planus?

Updated: Feb 24, 2020
  • Author: Tsu-Yi Chuang, MD, MPH, FAAD; Chief Editor: William D James, MD  more...
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Answer

Corticosteroids

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli. Topical steroids may be as effective as systemic steroids. Class I or II steroids in ointment form reduce pruritus in cutaneous lichen planus, but they have not been proven to induce remission.

Prednisone

Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. Use with extreme caution in children. The pediatric dose is determined more by severity of the condition than by age or weight.

Betamethasone topical (Diprolene, Celestone, Luxiq)

Betamethasone is for inflammatory dermatosis responsive to steroids. It decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. Use with extreme caution in pediatric patients. Children have a larger skin surface area to body weight ratio and less developed, thinner skin, which may result in greater amounts of topical steroid being absorbed compared with adults. Use nonfluorinated topical corticosteroids.

Triamcinolone (Aristospan, Kenalog)

Triamcinolone is for inflammatory dermatoses responsive to steroids. It decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. Local injections have been reported to be effective.

Halobetasol (Ultravate, Halonate)

Halobetasol is used for inflammatory dermatoses responsive to steroids. It decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability. Use with extreme caution in pediatric patients. Children have a larger ratio of skin surface area to body weight and less developed, thinner skin, which may result in greater amounts of topical steroid being absorbed compared with adults. Use nonfluorinated topical corticosteroids.


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