Which medications in the drug class Retinoid-like Agents are used in the treatment of Lichen Planus?

Updated: Feb 24, 2020
  • Author: Tsu-Yi Chuang, MD, MPH, FAAD; Chief Editor: William D James, MD  more...
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Answer

Retinoid-like Agents

These agents modulate cell proliferation.

Isotretinoin (Amnesteem, Claravis, Myorisan, Sotret)

Isotretinoin is an oral agent that treats serious dermatologic conditions. It is a synthetic 13-cis isomer of the naturally occurring tretinoin (trans- retinoic acid). Both agents are structurally related to vitamin A. Isotretinoin decreases sebaceous gland size and sebum production. It may inhibit sebaceous gland differentiation and abnormal keratinization.

Tretinoin topical (Retin-A, Avita, Renova, Atralin, Tretin-X)

Tretinoin may be effective for oral lichen planus but not for cutaneous disease. It inhibits microcomedo formation and eliminates existing lesions. Tretinoin makes keratinocytes in sebaceous follicles less adherent and easier to remove. It is available as 0.025%, 0.05%, and 0.1% creams and 0.01% and 0.025% gels.

Acitretin (Soriatane)

Acitretin is a retinoic acid analog, like etretinate and isotretinoin. Etretinate is the main metabolite and has demonstrated clinical effects close to those seen with etretinate. Its mechanism of action is unknown.


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