Which medications in the drug class Immunosuppressants are used in the treatment of Lichen Planus?

Updated: Feb 24, 2020
  • Author: Tsu-Yi Chuang, MD, MPH, FAAD; Chief Editor: William D James, MD  more...
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These agents modulate the immune system.

Cyclosporine (Sandimmune, Neoral, Gengraf)

Topical treatment with cyclosporine under occlusion has been efficacious for genital lesions and may be beneficial in hypertrophic lesions. Mouthwash or oil-based solutions have been effective for oral lichen planus but seem to be no better than corticosteroids. Systemic treatment has been used for severe resistant cutaneous disease, oral or ulcerative foot involvement, and lichen planopilaris of the scalp.

The pediatric population may require higher or more frequent dosing because of accelerated clearance; use with extreme caution.

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