Which medications in the drug class Psoralen phototherapy agents are used in the treatment of Granuloma Annulare?

Updated: Oct 15, 2020
  • Author: Ruby Ghadially, MBChB, FRCP(C)Derm; Chief Editor: William D James, MD  more...
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Psoralen phototherapy agents

These agents inhibit cell proliferation.

Methoxsalen plus UVA (8-MOP, Oxsoralen)

Methoxsalen plus UVA inhibits mitosis by binding covalently to pyrimidine bases in DNA when photoactivated by UVA. It may have a direct cytotoxic effect on activated histiocytes, fibroblasts, and lymphocytes in the dermal infiltrate of lesions. Methoxsalen plus UVA may control lymphokine production through modulation of activated lymphocytes.

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