Which medications in the drug class Psoralen phototherapy agents are used in the treatment of Granuloma Annulare?

Updated: Oct 29, 2018
  • Author: Ruby Ghadially, MBChB, FRCP(C)Derm; Chief Editor: William D James, MD  more...
  • Print
Answer

Psoralen phototherapy agents

These agents inhibit cell proliferation.

Methoxsalen plus UVA (8-MOP, Oxsoralen)

Methoxsalen plus UVA inhibits mitosis by binding covalently to pyrimidine bases in DNA when photoactivated by UVA. It may have a direct cytotoxic effect on activated histiocytes, fibroblasts, and lymphocytes in the dermal infiltrate of lesions. Methoxsalen plus UVA may control lymphokine production through modulation of activated lymphocytes.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!